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For larval, pupal, and adult stages, warmer temperatures encourage faster maturation but also faster senescence, while colder climates allow the budworm to mature at a slower rate

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Chronic exposure has been correlated with a 2.5-fold increase in pro-inflammatory cytokines, such as IL-6 and TNF-, which are well-documented contributors to tumor progression through sustained inflammation and immune system modulation [30]

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